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. 2010 Oct;21(10):1732–1744. doi: 10.1681/ASN.2010020143

Figure 9.

Figure 9.

NLRP3 mRNA is expressed in human nondiabetic kidney disease. RNA is isolated from renal biopsies of patients with nondiabetic kidney disease. Normal n = 16; IgA nephropathy (IgA) n = 9; minimal change disease (MCD) n = 3; membranous glomerulonephritis (MGN) n = 3; crescentic GN (CrGN) n = 5; lupus nephritis (SLE) n = 3; secondary FSGS n = 9; ATN n = 7; hypertension/vascular nephrosclerosis (HTN) n = 4. (A) NLRP3 mRNA expression is assessed by quantitative real-time PCR. Values are normalized to endogenous 18S mRNA expression levels (mean NLRP3 mRNA expression, normal versus disease, all P < 0.01). (B) Scatter plot of NLRP3 mRNA expression (log) against renal function (creatinine, μmol/L) in patients with nondiabetic kidney disease (r = 0.51, P < 0.01; n = 33).