Table 1.
Effects of MAPK Inhibitors on Reducing Blunt Impact Induced PG Depletion
| Group | [PG] μg/mg wet cartilage |
95% Confidence Intervals |
P | |||
|---|---|---|---|---|---|---|
| Mean | S.D. | N | Upper Limit | Lower Limit | ||
| Non-impacted control | 65.0 | 2.65 | 3 | 68 | 62 | 0.0007 |
| DMSO Only | 64.7 | 7.51 | 3 | 73.2 | 56.2 | 0.0062 |
| D. + I., −I. | 38.5 | 4.17 | 3 | 43.22 | 33.78 | N/A |
| D. + I., −A. | 45.9 | 3.49 | 3 | 49.85 | 41.95 | 0.0779 |
| Impact Only, −I. | 47.4 | 8.14 | 3 | 56.61 | 38.19 | 0.1672 |
| Impact Only, −A. | 42.6 | 4.92 | 3 | 48.17 | 37.03 | 0.3327 |
| SB203580 Only | 57.2 | 4.33 | 3 | 62.1 | 52.3 | 0.0057 |
| SB80 + I., −I. | 54.1 | 7.18 | 3 | 62.22 | 45.98 | 0.0313 |
| SB80 + I., −A. | 53.3 | 8.37 | 3 | 62.77 | 43.83 | 0.0518 |
| SB202190 Only | 59.6 | 6.01 | 3 | 66.4 | 52.8 | 0.0075 |
| SB90 + I., −I. | 75.2 | 15.71 | 3 | 92.98 | 57.42 | 0.0174 |
| SB90 + I., −A. | 70.7 | 13.32 | 3 | 85.77 | 55.63 | 0.0162 |
| U0126 Only | 54.2 | 9.56 | 3 | 65.02 | 43.38 | 0.0596 |
| U. + I., −I. | 71.5 | 4.49 | 3 | 76.58 | 66.42 | 0.0007 |
| U. + I., −A. | 66.2 | 3.83 | 3 | 70.53 | 61.87 | 0.0011 |
The PG contents in impacted cartilage or non-impacted controls were measured at Day 7of post-impaction. In impacted explants, cartilage directly from the impact zone (−I.) along with areas immediately adjacent to the zone (−A.) were assayed. All values were compared to that of the impact site of impacted cartilage treated with DMSO (D. + I., −I.).