Table 3.
Cellular co-localization of human kinases and their substrates
| Kinase family | Cellular localization of kinases | All substrates | Cytoplasmic substrates | Nuclear substrates | Cytoplasmic and nuclear substrates |
|---|---|---|---|---|---|
| PKA | Cytoplasm, nucleus | 151 | 96 | 74 | 21 |
| PKC | Cytoplasm, nucleus | 168 | 105 | 81 | 26 |
| PKB | Cell membrane, cytoplasm, nucleus | 63 | 49 | 32 | 19 |
| GRK | Cytoplasm | 19 | 18 | 2 | 2 |
| ROCK | Cytoplasm | 15 | 15 | 1 | 1 |
| BARK | Cytoplasm | 14 | 14 | 1 | 1 |
| CaMK2 | Cytoplasm | 36 | 29 | 11 | 6 |
| CaMK1 | Cytoplasm, nucleus | 14 | 5 | 8 | 2 |
| CK1 | Cytoplasm | 33 | 29 | 14 | 10 |
| ATM | Nucleus | 34 | 11 | 32 | 9 |
| DNAPK | Nucleus | 13 | 3 | 12 | 2 |
| RSK | Nucleus | 31 | 15 | 25 | 9 |
| CK2 | Nucleus | 123 | 46 | 91 | 17 |
| CDK | Nucleus | 121 | 34 | 79 | 30 |
| CDC2 | Nucleus | 95 | 37 | 66 | 17 |
| GSK | Nucleus | 34 | 15 | 23 | 9 |
| MAPK | Cytoplasm, nucleus | 140 | 59 | 91 | 29 |
| JNK | Cytoplasm, nucleus | 27 | 13 | 22 | 9 |
| P38 | Cytoplasm, nucleus | 35 | 15 | 22 | 4 |
| ERK | Nucleus | 88 | 41 | 63 | 18 |
| Aurora | Nucleus | 19 | 8 | 14 | 4 |
| IKK | Cytoplasm, nucleus | 12 | 10 | 8 | 6 |
| PAK | Cytoplasm | 25 | 19 | 6 | 1 |
| MAP2K | Cytoplasm, nucleus | 13 | 9 | 6 | 2 |
| Abl | Cytoplasm, nucleus | 26 | 18 | 13 | 5 |
| EGFR | Cell membrane, nucleus | 22 | 18 | 0 | 4 |
| InsR | Cell membrane | 9 | 9 | 0 | 0 |
| JAK | Membrane associated | 17 | 17 | 6 | 6 |
| Src | Membrane associated | 68 | 61 | 22 | 16 |
| FYN | Membrane associated | 21 | 16 | 9 | 5 |
| LCK | Membrane associated | 25 | 22 | 1 | 1 |
| LYN | Membrane associated | 20 | 17 | 3 | 3 |
| SYK | Membrane associated | 17 | 15 | 1 | 1 |
| Total | 3863 | 1661 | 2195 | 612 |
The bold value means P-value < 0.05.