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Scheme of the Role of the BI-1 Protein in the ROS-Induced Cell Death Pathway.
ROS cause mitochondrial permeability transition, ATP depletion, release of cytochrome c from the mitochondrial membranes, and lipid peroxidation, which cause ion leakage and cell death (Rao and Davis, 1999; Houot et al., 2001; Maxwell et al., 2002; Tiwari et al., 2002). BI-1 proteins, as components of the ER membrane, are involved in counteracting “oxidative stress.”
