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Anti-HMGB1 Ab treatment after the onset of IRI is protective in kidney IRI. Mice treated with α-HMGB1 Ab demonstrated significantly lower serum creatinine (A) and less tubular damage, assessed by semiquantitative scoring of hematoxylin- and eosin-stained tissue sections (B) compared with Ctrl Ig-treated mice at 24 hours after reperfusion. n = 5 to 7 per group.
