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HMGB1 blockade reduces tubular epithelial cell apoptosis in the kidney post-IRI measured by TUNEL assay. (A) Representative sections of kidney at 24 hours after sham operation or reperfusion. (B) The number of apoptotic tubular cells was significantly lower in anti-HMGB1 Ab-treated mice at day 1 post-IRI than in control mice (P < 0.05). The data shown are the means ± SD. n = 5 to 9 per group.
