Table 3.
Risk for moderate and severe CKD progression by number of modifiable risk factors
| No. of Risk Factors | No Decline in Kidney Function (Rate of eGFR Change >0 ml/min per year) (n = 1604) |
Mild CKD Progression (eGFR Loss 0 to 1 ml/min per year) (n = 426) |
Moderate CKD Progression (eGFR Loss 1 to 4 ml/min per year) (n = 1147) |
Severe CKD Progression (eGFR Loss >4 ml/min per year) (n = 994) |
|||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | OR | 95% CI | OR | 95% CI | |
| 1 | 1.449 | 0.872 to 2.407 | 1.000 | 1.664 | 0.957 to 2.892 | 2.271a | 1.192 to 4.327a |
| 2 | 1.192 | 0.737 to 1.928 | 1.000 | 1.794a | 1.284 to 2.358a | 2.586a | 1.397 to 4.784a |
| ≥3 | 1.291 | 0.788 to 2.116 | 1.000 | 1.999a | 1.169 to 3.418a | 4.233a | 2.269 to 7.897a |
Risk factors are modifiable/manageable risk factors that were significant in the multinomial model, including hypertension, diabetes, CVD, and PAD. The model is adjusted for all of the covariates including age, race, gender, cerebrovascular disease, CLD, dementia, and the intake of DMARDs or NSAIDs. The predictor variable representing the number of risk factors was treated as an ordinal variable.
aStatistically significant.