Table 4.
Rate of decline in kidney function and the risk for death
| Parameter | Adjusted HRa | 95% CI |
|---|---|---|
| No decline in kidney function (rate of eGFR change >0 ml/min per year) | 1.149 | 0.988 to 1.240 |
| Mild CKD progression (reference; eGFR loss 0 to 1 ml/min per year) | 1.000 | — |
| Moderate CKD progression (eGFR loss 1 to 4 ml/min per year) | 1.100 | 0.975 to 1.304 |
| Severe CKD progression (eGFR loss >4 ml/min per year) | 1.539 | 1.298 to 1.824 |
| Age per year | 1.047 | 1.041 to 1.053 |
| Hypertension | 0.747 | 0.612 to 0.912 |
| Diabetes | 1.282 | 1.169 to 1.406 |
| CVD | 1.670 | 1.475 to 1.891 |
| PAD | 1.221 | 1.092 to 1.365 |
| CLD | 1.611 | 1.469 to 1.767 |
| Hepatitis C | 1.825 | 1.426 to 2.334 |
| Dementia | 1.833 | 1.648 to 2.038 |
| DMARDs | 1.224 | 1.111 to 1.349 |
aCox survival model that is fully adjust for all above covariates and race, gender, cerebrovascular disease, and NSAIDs.