Table 1.
T12 histologic and baseline demographic characteristics of 151 noncomplicated, HLA-mismatched, LD KTxs
| Characteristic | Normal | IF Alone | IF+i | Pa |
|---|---|---|---|---|
| n (%) | 86 (57) | 45 (30) | 20 (13) | |
| T12 surveillance biopsy scores, original report (mean ± SD)b | ||||
| g | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.3 ± 0.6 | NS, 0.002, 0.002 |
| i | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.4 ± 0.6 | NS, 0.0001, 0.0001 |
| t | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.3 ± 1.0 | NS, 0.0001, 0.0001 |
| ci | 0.0 ± 0.0 | 1.2 ± 0.5 | 1.2 ± 0.5 | 0.0001, 0.0001, 0.9 |
| ct | 0.0 ± 0.0 | 1.2 ± 0.5 | 1.2 ± 0.7 | 0.0001, 0.0001, 0.7 |
| cv | 0.3 ± 0.5 | 0.8 ± 0.7 | 0.5 ± 0.8 | 0.0001, 0.4, 0.1 |
| ah | 0.1 ± 0.3 | 0.3 ± 0.5 | 0.5 ± 0.8 | 0.001, 0.1, 0.9 |
| T12 surveillance biopsy scores, blinded reread (mean ± SD [% with score ≥1]) | ||||
| total i | ND | 0.07 ± 0.26 (6%) | 1.81 ± 0.93 (100%) | – , – , 0.0001 |
| Recipient | ||||
| age at transplantation (years, mean ± SD) | 52 ± 12 | 51 ± 15 | 47 ± 17 | 0.5 |
| female gender (%) | 45 | 36 | 55 | 0.3 |
| Donor | ||||
| age at transplantation (years, mean ± SD) | 40 ± 11 | 44 ± 12 | 46 ± 14 | 0.1 |
| female gender (%) | 55 | 47 | 55 | 0.7 |
| GFRu/2 (Cioth ml/min; mean ± SD)c | 59 ± 11 | 60 ± 12 | 55 ± 11 | 0.2 |
ND, not done.
aP values for histology scores based on Wilcoxon rank sum test of normal versus IF alone; normal versus IF+i, and IF alone versus IF+i, respectively. P values for clinical indices given for ANOVA.
bBy definition, v and cg scores were 0 for all biopsies.
cCalculated predonation allograft function.