Table 1.
Clinical studies on the relationship between fetuin-A and extraosseous calcification and/or mortality
| Reference | Subjects | Centrifugation | Analytic Methods | Results |
|---|---|---|---|---|
| Ketteler et al. (2003)11 | HD patients | ND | Original indirect ELISA | Serum fetuin-A deficiency enhances mortality. |
| Mehrotra et al. (2005)16 | Patients with type 2 diabetes | ND | Original indirect ELISA | Serum fetuin-A positively correlates with CACS. |
| Moe et al. (2005)1 | Patients with stage 5 CKD | ND | Nephelometry | Low serum fetuin-A correlates with increased CACS. |
| Stenvinkel et al. (2005)12 | Patients with stage 5 CKD | ND | ELISA (ED) | Low serum fetuin-A associates with increased mortality. |
| Wang et al. (2005)13 | PD patients | ND | ELISA (ED) | Low fetuin-A associates with valvular calcification and mortality. |
| Honda et al. (2006)39 | Patients with stage 5 CKD | ND | Nephelometry | Low serum fetuin-A predicts higher mortality. |
| Hermans et al. (2006)18 | HD and PD patients | 15,000 × g | Nephelometry | Low fetuin-A does not predict 60-minute aortic stiffness. |
| Jung et al. (2006)17 | HD patients | 520 × g | ELISA (BV) | Serum fetuin-A levels do not correlate with CACS. |
| Cozzolino et al. (2006)40 | HD patients | ND | ELISA (ED) | Low fetuin-A correlates with increased cardiovascular calcification. |
| Mori et al. (2007)14 | Healthy subjects | ND | ELISA (BV) | Serum fetuin-A levels associate with carotid artery stiffness. |
| Russo et al. (2007)41 | Patients with stages 3 through 5 CKD | ND | ELISA (ED) | Serum fetuin-A is lower in patients with CAC. |
| Hermans et al. (2007)42 | HD and PD patients | 15,000 × g | Nephelometry | Low serum fetuin-A predicts 60-minute high mortality. |
| Ix et al. (2007)43 | Patients with CAD | 15,000 × g | Nephelometry | Low fetuin-A associates with 60-minute increased mitral annular calcification. |
| Ix et al. (2007)19 | Patients with stages 3 and 4 CKD | ND | ELISA (ED) | Serum fetuin-A levels are not related to mortality. |
| Mikami et al. (2008)15 | Patients with stages 1 through 5 CKD | ND | ELISA (ED) | Serum fetuin-A levels do not correlate with CACS. |
| Shroff et al. (2008)44 | HD and PD patients | ND | ELISA (ED) | Aortic PWV negatively correlates with serum fetuin-A. |
| Metry et al. (2008)45 | HD patients | ND | ELISA (ED) | Low serum fetuin-A associates with increased mortality only in the presence of inflammation. |
| Zheng et al. (2009)46 | HD patients | ND | ELISA (ED) | Low serum fetuin-A correlates with increased CACS. |
Published clinical studies on the relationship between fetuin-A and extraosseous calcification and/or mortality in adults are listed. Two analytical methods were used in these studies: ELISA and nephelometry. BV, BioVendor; CAC, coronary artery calcification; CAD, coronary artery disease; ED, Epitope Diagnostic; ND, not described; NRF, normal renal function; PD, peritoneal dialysis; PWV, pulse wave velocity. Bolded references are negative studies about fetuin-A.