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. 2010 Nov 19;404(1):56–69. doi: 10.1016/j.jmb.2010.08.008

Fig. 2.

Fig. 2

(a) Schematic showing the interactions between residues Asp191, Glu192, and Ser208, and ManNAc. A Schiff base is formed between pyruvate and Lys165. (b) X-ray crystal structure of NAL from H. influenzae in complex with the substrate analogue 4-oxo-sialic acid (PDB code 1F7B). The ketone at C4 is hydrated. The covalent bond with residue Lys165 is visible, and distances between the heteroatoms in residues Glu192, Asp191, and Ser208, and the heteroatoms in 4-oxo-sialic acid are highlighted.