Table 1.
Time course of the physiologic effect of DOCP treatment in wild-type mice
| Control (n) | Day 2 (n) | Day 4 (n) | Day 6 (n) | Day 8 (n) | |
|---|---|---|---|---|---|
| Change in BW (%) | 0 ± 0 (7) | 0.06 ± 1.2 (7) | 2.0 ± 1.2 (7) | 5.4 ± 1.4 (7)a,b | 6.1 ± 1.2 (7)a,b |
| Blood [Na+] (mM) | 148 ± 0.41 (13) | 150 ± 1.3 (3) | 153 ± 1.8 (4)c | 153 ± 0.80 (3)c | 150 ± 0.41 (3) |
| Blood [K+] (mM) | 3.9 ± 0.08 (14) | 3.5 ± 0.12 (4) | 3.5 ± 0.17 (4) | 2.9 ± 0.21 (3)c | 2.8 ± 0.07 (3)b,c |
| Blood [Cl−] (mM) | 118 ± 0.51 (13) | 120 ± 1.8 (3) | 116 ± 0.95 (4) | 117 ± 0.35 (3) | 111 ± 0.82 (3)a,b,c,d |
| Blood [HCO3−] (mM) | 18 ± 0.51 (14) | 19 ± 0.87 (4) | 20 ± 1.2 (4) | 20 ± 0.53 (3) | 23 ± 2.0 (3)c |
BW, body weight. Day signifies days of DOCP treatment.
aSignificant difference from day 2.
bSignificant difference from day 4.
cSignificant difference from control.
dSignificant difference from day 6.