Figure 7.
UFP exposure leads to upregulation of antioxidant genes in the liver. mRNA levels for antioxidant genes were determined by quantitative PCR in the livers of chow-fed mice exposed to CAPs for 40 days. Values are expressed as the means±SEM of mRNA levels normalized by β-actin mRNA. Ten samples per group were assayed in duplicate. Statistical analysis was performed by 1-way ANOVA (1-tailed Fisher PLSD; *P<0.05). ATF4 indicates activating transcription factor 4; GST-Ya, glutathione S-transferase Ya; NQO-1, NAD(P)H-quinone oxidoreductase 1; SOD2, superoxide dismutase 2.