Table 3.

Effect of co-administration of dalcetrapib 900 mg with ezetimibe on cholesteryl ester transfer protein (CETP) activity and mass

	Mean ± SD CETP activity (%)			Mean ± SD CETP mass (µg ml−1)
	Dalcetrapib 900 mg alone	Dalcetrapib 900 mg + ezetimibe	Ezetimibe alone	Dalcetrapib 900 mg alone	Dalcetrapib 900 mg + ezetimibe	Ezetimibe alone
n	25*	27†	22	25*	27†	22
Pre-dose day 1	84.5 ± 14.6	87.4 ± 14.2	85.0 ± 12.6	1.9 ± 0.4	1.9 ± 0.4	2.1 ± 0.4
Day 7‡	54.8 ± 16.3	51.6 ± 12.2	87.7 ± 13.4	2.8 ± 0.8	2.8 ± 0.5	1.7 ± 0.3
Percent change	−37.8	−41.5	3.1	44.6	46.5	−18.0

^*n = 24 at day 7.

^†n = 26 at day 7.

^‡CETP activity measured 6 h post-dose; CETP mass measured pre-dose.