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In normal cells (upper panel), alternative NHEJ pathway (Alt NHEJ) is a minor DSB pathway repair pathway compared with DNA-PK-dependent NHEJ (Classic NHEJ). In cancer cells (lower panel), the steady state levels of key DNA-PK-dependent NHEJ proteins are reduced whereas the steady state levels of key alternative NHEJ are increased. This results in increased activity of the Alt NHEJ pathway and reduced activity of the DNA-PK-dependent NHEJ (CNHEJ) pathway
