Table 2.
Guide for quantitative histological analysis.
| Hard tissue response at bone-scaffold Interface | |
|---|---|
| Description | Score |
| Direct bone to implant contact without soft tissue interlayer | 4 |
| Remodeling lacuna with osteoblasts and/or osteoclasts at surface | 3 |
| Majority of implant is surrounded by fibrous tissue capsule | 2 |
| Unorganized fibrous tissue (majority of tissue is not arranged as a capsule) | 1 |
| Inflammation marked by an abundance of inflammatory cells and poorly organized tissue | 0 |
|
Hard tissue response within the pores of the scaffold | |
| Description | Score |
| Tissue in pores is mostly bone | 4 |
| Tissue in pores consists of some bone with mature, dense fibrous tissue and/or a few inflammatory response elements | 3 |
| Tissue in pores is mostly immature fibrous tissue (with or without bone) with blood vessels and young fibroblasts invading the space with few macrophages present | 2 |
| Tissue in pores consists mostly of inflammatory cells and connective tissue components in between (with or without bone) OR the majority of the pores are empty or filled with fluid | 1 |
| Tissue in pores is dense and exclusively of inflammatory type (no bone present) | 0 |
|
Extent of bone formation within the defect | |
| Description | Score |
| 75–100% of defect consists of bone | 4 |
| 50–74% of defect consists of bone | 3 |
| 25–49% of defect consists of bone | 2 |
| 1–24% of defect consists of bone | 1 |