Table 2.

Cue Reactivity Task: BOLD activations for main effects (neutral/gambling/smoking-related pictures versus low-level baseline pictures); group interactions (gambling pictures versus neutral pictures, and smoking-related pictures versus neutral pictures); correlations between BOLD activations and self-reported craving

	Neutral versus baseline					Gambling versus baseline					Smoking-related versus baseline					Gambling versus neutral					Smoking-related versus neutral
		MNI coordinates					MNI coordinates					MNI coordinates					MNI coordinates					MNI coordinates
Main effects	L/R	x	y	z	Z value	L/R	x	y	z	Z value	L/R	x	y	z	Z value	L/R	x	y	z	Z value	L/R	x	y	z	Z value
Prefrontal
Dorsolateral
		−42	9	33	7.43	L	−42	12	33	7.44											L	−3	54	36	5.17
		42	15	30	7.42	R	54	24	30	7.77	R	42	15	33	6.92	L	−9	27	57	5.99
Ventrolateral	L	−30	33	−9	5.78		−33	33	12	6.59											L	−33	48	6	3.87
	R	36	36	−6	6.32		36	33	−6	7.52	R	36	33	−6	5.59
Medial																					R	3	54	0	4.75
Temporal
Middle temporal		−33	−18	−21	6.43	L	−30	−21	−21	6.53	L	−30	−15	−15	6.77						L	−39	6	−15	4.83
	R	33	−15	−15	7.29	R	30	−21	−21	7.22	R	33	−15	−15	6.58
Medial temporal
Parahippocampal gyrus	L	−27	−33	−21	12.01	L	−33	−48	−18	7.90	L	−24	−33	−18	7.80	L	−27	−45	−15	6.07
	R	27	−48	−15	14.30	R	33	−48	−18	11.00	R	36	−48	−24	13.25	R	33	−45	−12	7.06
Amygdala region						L	−21	−6	−18	8.60	L	−21	−6	−15	7.83
						R	24	−6	−18	9.76	R	21	−6	−15	7.81
Occipital lobe
Occipital gyrus		−27	−84	−9	15.35		−24	−84	−6	12.23		−30	−84	−9	14.24	L	−36	−66	27	5.48	L	−45	−63	33	5.86
		−39	−78	9	13.68		−33	−72	21	8.90		−36	−81	12	13.65	R	45	−63	30	5.49	R	45	−63	39	4.80
Fusiform gyrus	R	36	−45	−15	10.39	R	39	−63	−15	10.28	R	39	−63	−15	11.15	R	60	−54	12	5.86	R	60	−36	−3	5.12
Occipital gyrus		27	−84	−9	11.50		24	−84	−15	15.03		24	−84	−15	13.65
		24	−81	12	8.41		24	−90	12	12.85		24	−90	12	12.65
Posterior thalamus	L	−18	−30	−3	11.58	L	−21	−30	−3	10.21	L	−21	−30	−3	11.27
	R	18	−30	−3	9.43	R	21	−30	−3	10.94	R	21	−30	−3	6.92
Group Interactionsa
Gambling vs. Neutral Pictures	Problem Gamblers > Healthy Controls					Problem Gamblers > Heavy Smokers
		MNI coordinates					MNI coordinates
	L/R	x	y	z	Z value	L/R	x	y	z	Z value
Prefrontal						L	−48	9	33	3.64
Dorsolateral	R	39	7	30	3.22	R	45	0	42	4.31
Ventrolateral						L	−42	24	3	3.30
Medial Temporal
Parahippocampal Gyrus	L	−18	−24	−21	3.43	L	−27	−45	−15	4.04
	R	21	−27	−21	3.52	R	27	−36	−21	4.01
						R	30	−60	−15	3.45
Amygdala						L	−21	9	−18	3.54
	R	15	0	−15	3.34	R	15	5	−10	3.43
Occipital/Temporal junction						R	57	−60	3	3.56
Middle Occipital Gyrus	L	−33	−78	12	3.40	L	−33	−78	12	4.89
		−39	−72	12		R	27	−72	33	3.20

^aGroup interaction are reported at P < 0.001 unless indicated otherwise.

BOLD = blood oxygenation level-dependent; MNI = Montreal Neurological Institute.