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. 2010 Oct 20;85(1):357–365. doi: 10.1128/JVI.01694-10

FIG. 2.

FIG. 2.

Pathogenicity of rNY1682-WT, rNY1682-E158G, and rNY1682-E627K viruses in mice. Six-week-old female BALB/cJ mice (n = 5/group) were inoculated intranasally with 50 μl containing 105 TCID50 of different recombinant viruses (rNY1682-WT [WT], rNY1682-E158G [E158G], or rNY1682-E627K [E627K]) or mock inoculated (Mock). (A) Morbidity was assessed by weight changes over a 14-day period and is graphed as a percentage of the animals' weights on the day of inoculation (day 0). The average body weight for each group is shown, with error bars representing the SD. *, an F test indicated that the weight loss caused by rNY1682-E158G was significantly greater than that caused by rNY1682-WT (P < 10−13). (B) Mortality associated with infection by the recombinant virus (rNY1682-WT [WT], rNY1682-E158G [E158G], or rNY1682-E627K [E627K]) was also examined.