FIG. 6.
Inflammatory, IFN, and Th1/Th2 responses in monkeys infected with MVwt.STAT1blind or MVwt. Changes in mRNA expression levels in PBMC are shown as bar histograms. The results from MVwt. STAT1blind-infected monkeys are shown on the left panels; previously published results for MVwt-infected monkeys are shown on the right panels (14). The level of mRNA for each cytokine was normalized to 1 at day 0 for each monkey. Each histogram shows the fold change in mRNA levels at days 3, 7, and 14 postinfection. The results of individual monkeys are shown in the same order for all cytokines and time points. The data for MVwt-infected monkeys are only available for days 7 and 14. (A) Cytokines relevant for inflammation (TNF-α and IL-6). (B) IFN type I (IFN-α and IFN-β) and IFN-stimulated genes (MxA and OAS). (C) Cytokines involved in the Th1 and Th2 response (IL-12, IFN-γ, IL-2, and IL-4).