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Viral RNA replication is required for P body disruption. (A) HeLa cells were infected with PV for 2, 4, and 6 h in the presence of 2 mM guanidine-HCl. The cells were fixed and stained with two markers for P bodies, Dcp1a and Rck/p54. (B) Immunoblotting controls showing rapid cleavage of eIF4GI and lack of G3BP cleavage. P body (PB) number per cell (C) and average size (D) were quantitated for 30 randomly selected cells at each time point using NIH Image (**, P < 0.0005; *, P < 0.005).
