TABLE 1.
HCMV virion proteins analyzed in yeast two-hybrid analysis
| Protein type and ORF | Function | Role in infection |
|---|---|---|
| Capsid | ||
| UL46 | Major capsid-binding protein | Essential |
| UL48A | Smallest capsid protein | Essential |
| UL80 | Capsid assembly protein | Essential |
| UL85 | Minor capsid protein | Essential |
| UL86 | Major capsid protein | Essential |
| Tegument/uncharacterized | ||
| UL24 | Unknown | Dispensable |
| UL25 | Unknown | Dispensable |
| UL26 | Transcriptional regulation | Augmenting |
| UL32 | Late phase maturation | Essential |
| UL35 | Transcription/particle formation | Augmenting |
| UL43 | Unknown | Dispensable |
| UL44 | DNA replication | Essential |
| UL45 | Unknown | Dispensable |
| UL47 | Unknown | Augmenting |
| UL48 | Ubiquitin-specific protease | Essential |
| UL69 | Transcriptional regulation | Augmenting |
| UL71 | Unknown | Essential |
| UL82 | Transcriptional regulation | Augmenting |
| UL83 | Lower matrix protein | Dispensable |
| UL84 | DNA replication | Essential |
| UL88 | Unknown | Dispensable |
| UL94 | Unknown | Essential |
| UL96 | Unknown | Essential |
| UL97 | Protein kinase | Augmenting |
| UL99 | Late phase maturation | Essential |
| UL103 | Unknown | Augmenting |
| UL104 | DNA packaging/cleavage | Essential |
| UL112 | DNA replication | Augmenting |
| US22 | Unknown | Dispensable |
| US23 | Unknown | Augmenting |
| US24 | Unknown | Dispensable |
| IRS1 | Transcription | Dispensable |
| TRS1 | Transcription/egress | Augmenting |