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. 2000 Nov 1;106(9):1095–1103. doi: 10.1172/JCI10753

Figure 1.

Figure 1

Impaired growth of GHR–/– mice. (a) Growth curves of total body length (left) and femoral length (right) in wild-type (+/+) and GHR–/– (–/–) mice (n = 8 per group). AP < 0.01, and BP < 0.001 vs. wild-type. (b) Toluidine blue–stained proximal tibial sections from wild-type and GHR–/– mice at 2, 3, 4, 6, and 10 weeks. Horizontal bars indicate limits of the proliferative (Prol) and hypertrophic (Hyp) zones. Scale bar, 100 μm. (c) Growth-plate and proliferative-zone width (Prol Z width) were reduced in GHR–/– mice (open) versus wild-type littermates (filled); n = 8 per group. AP < 0.05, BP < 0.01, and CP < 0.001 vs. wild-type. (d) Total femoral BMD (left) in 16-week-old littermates in wild-type (filled), heterozygote (gray, GHR+/–), and knockout (open, GHR–/–) mice. Proximal femoral BMC (right) at 8, 16, and 24 weeks of age in wild-type (filled), GHR+/– (gray), and GHR–/– (open) mice (n = 8 per group). AP < 0.05 and BP < 0.0001 vs. wild-type; CP < 0.001 and DP < 0.01 vs. same transgene group at previous time point.