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Schematic representation of cloned SIV variants. Combinations of amino acid substitutions in the potential O-linked site in gp120 were introduced into the SIVmac239 proviral backbone. SIV variants Jacalin1 to Jacalin8 were based on changes present in the jacalin-selected population. Amino acid substitutions introduced in SIV01 to SIV07 were designed to disrupt the serine-threonine-rich stretch (amino acids 128 to 139).
