Table 2.

Changes in polysomnographic parameters following 8 weeks of treatment^*†(change from baseline; median)

	Placebo N = 50	SXB 4.5 g N = 59	SXB 6 g N = 49	SXB 9 g N = 35
Total Sleep Time (min)
1st Half	0.50	−0.50	2.00	3.00
2nd Half	−1.75	5.00	4.50	10.50
TOTAL	0.25	0.00	13.00	18.00
	—	NS	NS	p = 0.049
Total NREM Sleep (min)
1st Half	−2.75	−1.50	4.00	15.50
2nd Half	1.75	15.00	17.00	40.50
TOTAL	2.00	10.00	24.00	51.50
	—	NS	p = 0.010	p < 0.001
Total REM Sleep (min)
1st Half	−0.75	−1.00	−3.50	−5.50
2nd Half	2.00	−5.00	−4.50	−17.00
TOTAL	−1.00	−6.00	−7.00	−22.00
	—	NS	NS	p = 0.026
REM Sleep Latency (min)
	0.00	−1.00	−1.50	6.00
	—	p = 0.521	p = 0.203	p = 0.547
Stage 1 Sleep (min)
1st Half	−2.75	−3.00	−5.00	−7.50
2nd Half	1.25	−1.50	−9.50	−14.00
TOTAL	−2.25	−9.50	−13.50	−22.50
	—	p = 0.086	p < 0.001	p < 0.001
Stage 2 Sleep (min)
1st Half	1.50	−1.00	−5.00	−4.50
2nd Half	0.25	12.00	13.50	24.00
TOTAL	3.50	9.50	13.00	31.50
	—	NS	NS	NS
Stage 3 and 4 Sleep (min)
1st Half	−0.25	1.00	10.00	20.50
2nd Half	0.00	0.50	4.50	26.50
TOTAL	0.00	3.00	21.00	52.50
	—	p =	p < 0.001	p < 0.001
Wake After Sleep Onset (min)
1st Half	−0.50	0.25	−0.25	−1.00
2nd Half	−2.00	−1.50	−2.75	−9.50
TOTAL	2.00	−5.75	−3.75	−22.00
	—	NS	NS	p = 0.052
Sleep Stage Shifts Per Hour
1st Half	−1.82	−1.51	−1.18	−1.91
2nd Half	−0.88	−0.45	−0.85	0.00
AVERAGE	−1.03	−1.36	−1.11	−0.68
	—	NS	NS	NS
Delta Power (microvolts^2/Hz)
1st Half	85.42	8413.11	14624.92	25164.43
2nd Half	−3538.83	7725.27	19726.61	32951.43
AVERAGE	−1102.98	7166.20	14736.32	28796.65
	—	p = 0.006	p < 0.001	p < 0.001
Nocturnal Awakenings
1st Half	−1.50	−2.00	−3.00	−3.00
2nd Half	−0.00	−3.00	−5.00	−9.00
TOTAL	−0.50	−5.00	−8.00	−12.00
	—	NS	p = 0.005	p = 0.009

^*Statistical significance was established compared to placebo. NS = not significant.

^†Expressed as medians following transformation of non-normal data.