Table 3.
Summary of Immunohistochemical Data
Case No. | Survl. | PMD | Age | Axonal Bulbs | Soma | Aβ Plaques | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Aβ | APP | NF | BACE | PS1 | Kinesin | NEP | NEP | |||||
Acute Cases | ||||||||||||
1 | 48 h | 43 h | 16 | ++ | +++ | +++ | ++ | ++ | + | ++ | + | ++ |
2 | 96 h | 48 h | 59 | + | + | ++ | + | + | + | + | − | ++ |
3 | 120 h | 144 h | 59 | − | + | + | + | + | + | − | − | − |
4 | 19 h | 27 h | 71 | − | + | + | + | + | + | − | − | − |
5 | 37 h | 72 h | 17 | ++ | +++ | +++ | ++ | + | ++ | ++ | + | ++ |
Long‐Term cases | ||||||||||||
1 | 27 d | 96 h | 31 | + | + | + | + | − | + | ++ | +++ | − |
2 | 5 w | 47 h | 76 | + | + | + | − | − | + | + | + | − |
3 | 6 w | 32 h | 76 | + | + | + | − | − | + | − | + | − |
4 | 7 w | 90 h | 50 | ++ | ++ | ++ | + | + | + | ++ | +++ | − |
5 | 4 w | 24 h | 18 | ++ | ++ | ++ | + | + | + | ++ | − | − |
6 | 4 w | 81 h | 23 | ++ | ++ | ++ | + | + | + | ++ | +++ | − |
7 | 12 w | 64 h | 18 | + | + | + | + | − | + | + | ++ | − |
8 | 16 w | 75 h | 79 | + | + | + | + | + | + | − | − | − |
9 | 5 m | 120 h | 65 | + | ++ | + | + | + | + | ++ | +++ | + |
10 | 5 m | 120 h | 56 | + | + | + | + | − | + | − | − | − |
11 | 6 m | 72 h | 31 | ++ | + | + | + | + | + | ++ | +++ | − |
12 | 6 m | 12 h | 39 | + | + | ++ | + | + | + | − | − | − |
13 | 8 m | 72 h | 67 | + | + | ++ | + | + | + | + | +++ | − |
14 | 9 m | 192 h | 28 | + | + | + | + | + | + | − | − | − |
15 | 9 m | NK | 58 | + | + | + | + | + | + | − | − | − |
16 | 18 m | 24 h | 64 | + | + | + | − | − | − | − | − | − |
17 | 2 yr | 120 h | 48 | + | + | + | + | + | + | − | ++ | − |
18 | 3 yr | 20 h | 56 | + | ++ | + | − | + | − | − | ++ | − |
Control Cases | ||||||||||||
C1 | n/a | NK | 21 | − | − | − | − | − | − | − | − | − |
C2 | n/a | NK | 33 | − | − | − | − | − | − | − | − | − |
C3 | n/a | 4 d | 15 | − | − | − | − | − | − | − | − | − |
+ = fewer than 5 profiles; ++ = 6 to 15 profiles; +++ = greater than 15 profiles; PMD = post‐mortem delay; Survl = survival time post‐trauma; PS1 = presenilin‐1; BACE = beta‐site APP cleaving enzyme; APP = amyloid precursor protein; Aβ = amyloid beta; NF = neurofilament; NEP = neprilysin; NK = Not known.