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CTR2 activates the GTPases that control macropinocytosis. A, relative levels of total and phosphorylated Rac1 and cdc42 in CTR1(+/+), CTR1(+/+) CTR2(kd), CTR1(−/−), and CTR1(−/−) CTR2(kd) cells. B, relative levels of phosphorylated Akt.