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. Author manuscript; available in PMC: 2011 Apr 28.
Published in final edited form as: N Engl J Med. 2010 Oct 28;363(18):1727–1733. doi: 10.1056/NEJMoa1007056

Figure 3. Histologic and Immunohistochemical Analyses of IMT Samples from Patient 2.

Figure 3

A sample of the inflammatory myofibroblastic tumor (IMT) obtained on biopsy shows ganglion-like, plump epithelioid cells with abundant eosinophilic cytoplasm and nuclei with open chromatic and prominent nucleoli; scattered small lymphocytes are in the background (Panel A, hematoxylin and eosin). A different area of the tumor shows a prominent inflammatory component that is composed primarily of plasma cells, dense fibrous stroma, and scattered plump spindle and ganglion-like cells (Panel B, arrows; hematoxylin and eosin). Results of immunostaining for ALK are negative (Panel C), and FISH analysis shows no ALK rearrangement (Panel D).