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. 2011 Jan;336(1):47–55. doi: 10.1124/jpet.110.169797

Fig. 2.

Fig. 2.

A and B, metabolism of 14,15-EE5ZE (A) and effect of sEH inhibitor (AUDA) on 14,15-EE5ZE metabolism (B) in BCAs. 14,15-EE5ZE was incubated for 10 and 30 min in the presence and 30 min in the absence of BCA. Arteries were preincubated for 30 min with AUDA (1 μM) before incubation for 10 min with 14,15-EE5ZE (B). C, 13-HTDA was incubated for 10 and 30 min in the presence and absence of BCA. Medium was extracted and analyzed by LC/ESI-MS. sEH activity was expressed as the conversion of 14,15-EE5ZE to 14,15-DHE5ZE.