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. 2011 Jan;336(1):134–144. doi: 10.1124/jpet.110.170431

Fig. 3.

Fig. 3.

Whole-cell patch clamp recordings from hippocampal dentate gyrus granule cells. A, the left traces illustrate the averaged mIPSCs (from 100 single events) recorded from a granule neuron from a SL/SL mouse in the absence or presence of 0.15 and 0.30 mM isoflurane. The right traces show the averaged mIPSCs from an α2 ΗΑ/ΗΑ animal. Under control conditions, the decay time constant of mIPSCs recorded from HA/HA mice was reduced compared with SL/SL (P < 0.01). B, histogram summarizing the effects of isoflurane on decay time constants. Isoflurane dose-dependently increased the decay time constants in both genotypes, but the increase in HA/HA mice was reduced compared with SL/SL mice in response to 0.30 mM isoflurane. **, p < 0.01.