Fig. 1.
Ethanol modulation of GABA responses in wild-type (SL) and mutant (HA) α2β3γ2s GABAA receptors expressed in Xenopus oocytes. a, GABA responses in α2β3γ2s GABAA receptors. Pooled data are represented as mean ± S.E.M. (n = 7–8). Effects of ethanol were tested with EC5–10 GABA. *, p < 0.01, significant differences from wild type for the same concentration of ethanol (two-way ANOVA followed by Bonferroni post test). b, GABA responses in α2β2γ2s GABAA receptors. Pooled data are represented as mean ± S.E.M. (n = 4 each). **, p < 0.01, Student's t test; difference between responses in wild-type and mutant GABA receptors. c, the actual tracing from oocyte recording with α2β2γ2s GABAA receptors.