TABLE 1.
Summary of the behavioral effects of ethanol in HA/HA knockin mice
| Test | Behavior | Males | Females |
|---|---|---|---|
| 2-BC (ethanol) | EtOH (g/kg/24 h) | ↓ | = |
| Preference | ↓ | = | |
| Fluid intake (g/kg/24 h) | ↑ | = | |
| 2-BC (saccharin) | Preference | = | = |
| 2-BC (quinine) | Preference | ↓ | = |
| 1B-DID (short) | EtOH (g/kg/2 h) | = | ↑ |
| 1B-DID (long) | EtOH (g/kg/2 h) | ↑ | ↑ |
| 2B-DID | EtOH (g/kg/3 h) | ↑ | ↑ |
| Preference | ↑ | = | |
| Fluid intake (g/kg/3 h) | = | ↑ | |
| 2-BCI | EtOH (g/kg/24 h) | = | ↑ |
| Preference | ↑ | ↑ | |
| Fluid intake (g/kg/24 h) | = | ↑ | |
| CTA | Taste aversion | ↓ | ↓ |
| LORR | Duration (min) | ↑ | ↑ |
| EPM | Anxiety | = | = |
| Activity | ↓ | ↓ | |
| OF | Motor stimulation | ↓ | ↓ |
| Rotarod | Motor incoordination | = | = |
2-BC, two-bottle choice with 24-h access; 2-BCI, two-bottle choice with intermittent 24-h access; 1B-DID, limited access with one bottle; 2B-DID, limited access with two bottles; EPM, elevated plus maze; OF, open field. ↓, reduction of behavior in mutant mice; ↑, increase of behavior in mutant mice; =, no differences.