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. 2011 Jan;336(1):274–281. doi: 10.1124/jpet.110.172593

Fig. 2.

Fig. 2.

Cardioprotection with 5-day morphine-induced SLP and its long-term persistence. Data are shown for effects of SLP on myocardial infarct size (percentage of ventricular volume) (A) and recoveries for LVDP (percentage of baseline) (B) and end-diastolic pressure (mmHg) (C). Mice were subjected to 5-day morphine or placebo exposure followed by 0, 3, 5, or 7 days removal of morphine (or placebo). Hearts were then assessed for infarct development or functional recoveries after 25-min ischemia/45-min reperfusion. Data are mean ± S.E.M. *, P < 0.05 versus corresponding placebo group; †, P < 0.05 versus SLP alone. DW, days of stimulus withdrawal from SLP.