Table 4.
Results of Observed and Imputed SNPs at 11p13 Telomeric of CD44a
| SNP | Position (Mb) |
European |
Asian |
African American |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allelesb | MAF | GWAS | p | OR (95% CI)c | pmeta (OR, 95% CI) | Allelesb | MAF | p | OR (95% CI)c | Allelesb | MAF | p | OR (95% CI)c | ||
| rs2732552 | 35.041168 | C/T | 0.43 | 4.00E−03 | 9.03E−08 | 0.83 (0.77–0.89) | 1.82E−09 (0.82, 0.76–0.88) | C/T | 0.27 | 4.31E−04 | 0.80 (0.71–0.90) | T/C | 0.34 | 5.36E−03 | 0.81 (0.94–0.70) |
| rs2785202 | 35.041411 | C/G | 0.42 | 8.04E−08 | 0.83 (0.77–0.89) | C/G | 0.27 | 4.09E−04 | 0.80 (0.70–0.90) | G/C | 0.36 | 8.24E−04 | 0.77 (0.66–0.90) | ||
| rs2553772 | 35.042029 | G/T | 0.43 | 7.35E−08 | 0.82 (0.77–0.88) | G/T | 0.24 | 1.05E−04 | 0.76 (0.66–0.87) | N/A | N/A | N/A | N/A | ||
| rs2732550 | 35.044894 | G/T | 0.42 | 3.21E−07 | 0.83 (0.77–0.89) | G/T | 0.24 | 1.55E−04 | 0.76 (0.66–0.88) | G/T | 0.01 | 0.060 | 0.44 (0.19–1.03) | ||
| rs2732549 | 35.044975 | A/G | 0.43 | 1.58E−07 | 0.83 (0.77–0.89) | A/G | 0.24 | 1.34E−04 | 0.76 (0.66–0.88) | N/A | N/A | N/A | N/A | ||
| rs2732547 | 35.045259 | C/T | 0.42 | 1.44E−07 | 0.83 (0.77–0.89) | C/T | 0.27 | 2.07E−04 | 0.79 (0.69–0.89) | T/C | 0.41 | 6.55E−03 | 0.78 (0.65–0.93) | ||
| rs2785201 | 35.045414 | C/G | 0.42 | 1.70E−07 | 0.83 (0.77–0.89) | C/G | 0.21 | 2.69E−03 | 0.79 (0.68–0.92) | G/C | 0.41 | 5.29E−03 | 0.77 (0.64–0.93) | ||
| rs2732546 | 35.045661 | C/T | 0.43 | 1.79E−07 | 0.83 (0.77–0.89) | C/T | 0.27 | 6.04E−04 | 0.80 (0.70–0.91) | N/A | N/A | N/A | N/A | ||
| rs1895821 | 35.046097 | C/T | 0.43 | 2.64E−07 | 0.83 (0.77–0.89) | C/T | 0.26 | 3.45E−04 | 0.79 (0.70–0.90) | N/A | N/A | N/A | N/A | ||
| rs675970 | 35.04692 | G/A | 0.42 | 1.78E−07 | 0.83 (0.77–0.89) | G/A | 0.24 | 1.44E−04 | 0.76 (0.66–0.88) | N/A | N/A | N/A | N/A | ||
| rs1834459 | 35.049346 | A/G | 0.42 | 6.13E−07 | 0.83 (0.78–0.90) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | ||
| rs2732544 | 35.049527 | C/T | 0.43 | 3.82E−07 | 0.83 (0.77–0.89) | C/T | 0.26 | 5.98E−04 | 0.80 (0.70–0.91) | N/A | N/A | N/A | N/A | ||
| rs2785198 | 35.049605 | A/G | 0.42 | 5.90E−07 | 0.83 (0.78–0.90) | A/G | 0.26 | 6.63E−04 | 0.80 (0.70–0.91) | N/A | N/A | N/A | N/A | ||
| rs2785197 | 35.049646 | G/A | 0.43 | 3.64E−07 | 0.83 (0.77–0.89) | G/A | 0.26 | 3.95E−04 | 0.79 (0.70–0.90) | N/A | N/A | N/A | N/A | ||
| rs1116470 | 35.051067 | C/T | 0.43 | 2.86E−07 | 0.83 (0.77–0.89) | C/T | 0.25 | 1.72E−04 | 0.77 (0.67–0.88) | N/A | N/A | N/A | N/A | ||
| rs1116471 | 35.051208 | G/A | 0.43 | 3.16E−07 | 0.83 (0.77–0.89) | G/A | 0.25 | 1.96E−04 | 0.77 (0.67–0.88) | N/A | N/A | N/A | N/A | ||
| rs2785194 | 35.05183 | C/T | 0.43 | 2.75E−07 | 0.83 (0.77–0.89) | C/T | 0.25 | 1.96E−04 | 0.77 (0.67–0.88) | T/C | 0.29 | 0.015 | 0.81 (0.69–0.96) | ||
| rs2785193 | 35.052011 | C/A | 0.43 | 2.51E−07 | 0.83 (0.77–0.89) | C/A | 0.25 | 1.96E−04 | 0.77 (0.67–0.88) | N/A | N/A | N/A | N/A | ||
| rs2732540 | 35.052062 | G/A | 0.44 | 2.57E−06 | 0.84 (0.78–0.90) | G/A | 0.23 | 1.62E−04 | 0.77 (0.67–0.88) | N/A | N/A | N/A | N/A | ||
| rs1834460 | 35.052141 | C/T | 0.43 | 3.25E−07 | 0.83 (0.77–0.89) | C/T | 0.25 | 1.57E−04 | 0.77 (0.67–0.88) | T/C | 0.29 | 5.40E−03 | 0.79 (0.68–0.93) | ||
| rs2098878 | 35.052886 | G/A | 0.43 | 2.24E−07 | 0.83 (0.77–0.90) | G/A | 0.25 | 1.77E−04 | 0.77 (0.67–0.88) | A/G | 0.46 | 0.083 | 0.83 (0.67–1.02) | ||
| rs2553827 | 35.053243 | A/G | 0.43 | 4.34E−07 | 0.83 (0.78–0.89) | A/G | 0.25 | 1.52E−04 | 0.77 (0.67–0.88) | N/A | N/A | N/A | N/A | ||
| rs2553826 | 35.053334 | C/T | 0.43 | 2.49E−07 | 0.83 (0.77–0.89) | C/T | 0.25 | 1.52E−04 | 0.77 (0.67–0.88) | N/A | N/A | N/A | N/A | ||
| rs429503 | 35.053571 | T/G | 0.42 | 5.04E−07 | 0.83 (0.78–0.90) | T/G | 0.23 | 1.94E−04 | 0.77 (0.68–0.89) | N/A | N/A | N/A | N/A | ||
| rs63214363 | 35.053874 | T/A | 0.43 | 2.96E−07 | 0.83 (0.77–0.89) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | ||
| rs387619 | 35.054769 | C/T | 0.42 | 3.00E−03 | 7.71E−07 | 0.84 (0.78–0.90) | 1.46E−08 (0.82, 0.76–0.88) | C/T | 0.23 | 1.44E−03 | 0.80 (0.70–0.92) | C/T | 0.14 | 0.485 | 0.94 (0.81–1.11) |
N/A indicates SNPs that did not meet the quality control criteria after imputation.
a
Lines in bold indicate observed SNPs.
b
Major/minor.
c
OR calculated according to the minor allele identified in the European data set.