Figure 2.

CC Score Nomogram for Obtaining a Corresponding Individual Point Pretest Probability of Germline PTEN Mutation

The CC score is first derived by a sum of the weights of positive features that is provided in Table 4. To illustrate, three hypothetical cases are presented, each corresponding to a CC score of 5 points, 10 points, and 15 points, respectively. Case 1 may present with breast cancer at age 55 (1 point), with background of thyroid cancer at age 44 (4 points), with a final score of 5 and corresponding point probability < 1%. Case 2 may present with breast cancer at age 38 (4 points) and concurrent macrocephaly (6 points), with a final score of 10 and corresponding point probability of 3%. Case 3 may present with a single hamartomatous gastrointestinal polyp (10 points) found on endoscopy, Hashimoto's thyroiditis (4 points), and lipomas (1 point), for a final score of 15 and corresponding point probability of 10%.