Table 5.

Comparison of the CC Pediatric Criteria and Adult Score Relative to the NCCN 2010 Criteria

		Cleveland Clinic		Ohio State University
		Nonmutant	Mutant	Nonmutant	Mutant
Adult
CC scorea	Fails threshold	1426	10	445	8
	Meets threshold	476	95	267	102
	Sensitivity/specificity		90%/75%		93%/62%
	Concordance index	0.83c	0.83c	0.78	0.78
NCCN criteriab	Fails criteria	1310	27	474	17
	Meets criteria	592	78	238	93
	Sensitivity/specificity		74%/69%		85%/67%
	Concordance index	0.72	0.72	0.76	0.76
Pediatric
CC criteriaa	Fails threshold	6	0	7	1
	Meets threshold	58	28	68	46
	Sensitivity/specificity		100%/10%		98%/9%
NCCN criteriab	Fails criteria	5	3	56	20
	Meets criteria	59	25	19	27
	Sensitivity/specificity		89%/8%		56%/74%
Overall
CC scorea	Fails threshold	1432	10	493	11
	Meets threshold	533	124	294	146
	Sensitivity/specificity		93%/73%		93%/63%
	Concordance index	0.83c	0.83c	0.76	0.76
NCCN criteriab	Fails criteria	1315	30	530	37
	Meets criteria	650	104	257	120
	Sensitivity/specificity		78%/67%		76%/67%
	Concordance index	0.72	0.72	0.72	0.72

^aFor adults, using a threshold Cleveland Clinic (CC) score of 10 points and above for recommendation of PTEN testing.

^bNational Comprehensive Cancer Network (NCCN) criteria, 2010.

^cOptimism corrected with 200 bootstraps.