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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Free Radic Biol Med. 2010 Oct 23;50(1):27–36. doi: 10.1016/j.freeradbiomed.2010.10.702

Figure 6.

Figure 6

SVCT2 deficiency in macrophages suppresses NF-κB-related and anti-apoptotic genes. (A–C) Basal expression of mRNA for inflammation-related genes (COX-2, IL1β and IL6) in untreated SVCT2+/+ (■) and SVCT2−/− (□) macrophages from 3 mice in each group. Data are shown as mean ± SEM, with an asterisk indicating p < 0.05 compared to the control group. (D–G) SVCT2+/+ (■) and SVCT2−/− (□) macrophages from 3 mice in each group were treated with 50 nM LPS for 5 hours, followed by measurement of mRNA for NF-κB-related (IKKα, IKKβ) and anti-apoptotic (Gadd45β and Itch) genes. An asterisk indicates p < 0.05 compared to control LPS treatment for the respective group.