Table 1.

Myo1c mutations associated with hearing loss

Mutation	Location of mutation in motor domain	Phenotype of patientsa
Myo1c R156W	Immediately preceding switch 1	Bilateral sensorineural hearing loss
Myo1c V252A	In helix K in the upper 50 kDa domain	Moderate bilateral sensorineural hearing loss
Myo1c T380M	In helix O of transducer near switch 2	Progressive bilateral sensorineural hearing loss

^aData from Zadro et al. 2009 [16]