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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Trends Cell Biol. 2010 Oct 18;21(1):20–28. doi: 10.1016/j.tcb.2010.09.006

Figure 1. Sequence of human HVCN1 showing its arrangement in the membrane.

Figure 1

Two sites on the intracellular amino terminus have been shown to influence channel opening: phosphorylation of Thr29 strongly enhances opening in leukocytes [45], whereas the missense mutation M91T reduces it in airway epithelial cells [27]. Histidines constituting Zn2+ binding site(s) [8, 24, 25] are indicated, together with transmembrane domains (four rectangular boxes).