Effect of METH on the indirect indices of NO striatal production 3-nitrotyrosine (A) and L-citrulline (B). Mice (n=7) received METH (30 mg/kg, ip) and were sacrificed 4 hours post-injection. A group a mice received the neurokinin-1 receptor antagonist WIN-51,708 (5 mg/kg, ip) 30 minutes before METH. V/S, vehicle/saline; V/M, vehicle/METH; W/S, WIN-51,708/saline; W/M, WIN-51,708/METH. The number of cells staining positive for 3-NT or L-citrulline were counted manually in bright field as described. *P<0.05 (ANOVA).