Table 2.
Protection against challenge with 3 virulent Brucella species in mice vaccinated with 2 doses of gamma-irradiated B. neotomae and its recombinant strains.
| Challenge strain | Vaccine | Bacterial load in spleen log10 CFU (mean ± stdev) | Units of protectiona | P value vs corresponding control group |
|---|---|---|---|---|
| B.abortus 2308 | None (saline) | 5.27 ± 0.09 | - | - |
| B. neotomae | 3.32 ± 0.84 | 2.95 | 0.0015 | |
| B. neotomae/Bp26 | 2.29 ± 0.32 | 2.98 | 0.00006 | |
| B. neotomae/SOD | 3.24 ± 0.19 | 2.03 | 0.00005 | |
| B. suis 1330 | None (saline) | 5.71 ± 0.29 | - | - |
| B. neotomae | 2.13 ± 1.16 | 3.58 | 0.003 | |
| B. neotomae/Bp26 | 2.15 ± 0.81 | 3.56 | 0.0028 | |
| B. neotomae/SOD | 2.31 ± 0.99 | 3.4 | 0.0005 | |
| B. melitensis 16M | None (saline) | 5.66 ± 0.11 | - | - |
| B. neotomae | 3.62 ± 1.4 | 2.04 | 0.025 | |
| B. neotomae/Bp26 | 4.32 ± 0.43 | 1.34 | 0.003 | |
| B. neotomae/SOD | 3.33 ± 1.73 | 2.33 | 0.045 |
a
Units of protection were calculated by subtracting the mean log10 CFU for a vaccinated group from the mean log10 CFU of the corresponding saline control group.