Table 1.
Demographic and Clinical Characteristics
| Characteristic | No. | % |
|---|---|---|
| Total No. | 42 | 100 |
| Age, years | ||
| Median | 37 | |
| Range | 25-73 | |
| Race/ethnicity | ||
| White | 37 | 88 |
| Hispanic | 2 | 5 |
| Black | 2 | 5 |
| Asian | 1 | 2 |
| Prior colonoscopy | 34 | 80.1 |
| Prior EMB | 19 | 45.2 |
| Risk status | ||
| Mutation | ||
| MSH2 | 15 | 36 |
| MLH1 | 11 | 26 |
| MSH6 | 1 | 2 |
| Presumptive Lynch* | 4 | 9.5 |
| 50% risk for Lynch | 4 | 9.5 |
| Amsterdam II positive† | 3 | 7 |
| Other‡ | 4 | 9.5 |
| Parity | ||
| Nulliparous | 11 | 26 |
| Parous | 31 | 74 |
| Delivery method | ||
| Vaginal | 23 | 74.2 |
| Cesarean section | 8 | 25.8 |
Abbreviation: EMB, endometrial biopsy.
Presumptive Lynch: personal history of colon cancer with immunohistochemical loss of MMR expression but no identifiable gene mutation.
Amsterdam II criteria: each of the following criteria must be fulfilled: three or more relatives with an associated cancer (colorectal, endometrial, small intestine, ureter, or renal); two or more successive generations affected; one or more relatives diagnosed before the age of 50 years, one of whom should be a first-degree relative; familial adenomatous polyposis should be excluded in cases of colon cancer; tumors should be verified by pathologic examination.
Family history of colon and endometrial cancer not fulfilling Amsterdam criteria with inconclusive genetic testing or no testing available, Cowden's syndrome with need for routine colon cancer screening.