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Pseudokinases in action. (a) STRADα binding to LKB1 within the LKB1-STRAD-MO25 complex (PDBID 2WTK; [27••]). A-segment = activation segment, defined as the region between the DFG and APE motifs and comprises the activation and substrate binding (p + 1) loops [7]. (b) Structure of ILK-α-parvin complex (PDBID 3KMW; [36••]). (c) Structure of the asymmetric EGFR/EGFR dimer (PDBID 2GS2; [37••]). (d) Structure of the BRAF side-to-side dimer [58••] (PDBID 1UWH, [73]).
