Table 5.
Multivariable-adjusted* estimates of the additive effect of quartile/tertile of leukocytes on mean intercept and slope of BP trajectories over time, by race. Values are means (standard error).
| African-Americans |
Whites |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Quartile/Tertile (1=highest) |
Intercept (SE) |
P for trend |
Slope coefficient (SE) |
P for trend |
Intercept (SE) |
P for trend |
Slope coefficient (SE) |
P for trend |
|
| SBP | |||||||||
| Neutrophils | Q1 | 6.39 (1.71) | −0.25 (0.22) | 1.30 (1.01) | 0.001 (0.12) | ||||
| Q2 | 3.27 (1.63) | 0.0001 | −0.21 (0.22) | 0.31 | 0.56 (1.02) | 0.91 | 0.01 (0.13) | 0.04 | |
| Q3 | 1.09 (1.26) | 0.30 (0.16) | −0.16 (1.03) | −0.01 (0.13) | |||||
| Lymphocytes | Q1 | −5.78 (1.50) | 0.12 (0.20) | −1.68 (0.89) | 0.08 (0.11) | ||||
| Q2 | −6.39 (1.69) | <.0001 | 0.11 (0.23) | 0.58 | −1.72 (0.74) | 0.02 | 0.002 (0.09) | 0.61 | |
| Q3 | −2.46 (1.80) | 0.08 (0.25) | −1.16 (0.67) | 0.03 (0.08) | |||||
| Monocytes | T1 | 0.47 (1.29) | 0.66 | −0.04 (0.17) | 0.69 | −0.57 (0.69) | 0.31 | −0.06 (0.09) | 0.53 |
| T2 | −0.54 (1.32) | 0.15 (0.17) | 0.91 (0.68) | −0.12 (0.08) | |||||
| DBP | |||||||||
| Neutrophils | Q1 | 1.61 (0.99) | 0.12 (0.14) | 0.14 (0.62) | −0.002 (0.07) | ||||
| Q2 | 1.28 (0.94) | 0.08 | 0.09 (0.14) | 0.19 | 0.06 (0.62) | 0.51 | −0.02 (0.08) | 0.93 | |
| Q3 | −0.87 (0.73) | 0.28 (0.10) | −0.21 (0.63) | −0.01 (0.08) | |||||
| Lymphocytes | Q1 | −2.16 (0.87) | −0.12 (0.12) | −0.06 (0.55) | 0.05 (0.06) | ||||
| Q2 | −2.43 (0.98) | 0.01 | −0.11 (0.14) | 0.30 | −0.51 (0.45) | 0.51 | −0.05 (0.05) | 0.93 | |
| Q3 | −0.85 (1.04) | −0.03 (0.15) | −0.04 (0.41) | 0.02 (0.05) | |||||
| Monocytes | T1 | 1.15 (0.75) | 0.08 | −0.08 (0.10) | 0.33 | −0.22 (0.42) | 0.51 | −0.05 (0.05) | 0.51 |
| T2 | −0.52 (0.76) | 0.11 (0.25) | 0.36 (0.41) | −0.12 (0.05) | |||||
| MAP | |||||||||
| Neutrophils | Q1 | 3.22 (1.14) | 0.01 (0.15) | 0.53 (0.69) | −0.00 (0.08) | ||||
| Q2 | 1.94 (1.09) | 0.003 | −0.01 (0.15) | 0.73 | 0.22 (0.70) | 0.15 | −0.01 (0.08) | 0.90 | |
| Q3 | −0.21 (0.84) | 0.28 (0.11) | −0.20 (0.71) | −0.01 (0.08) | |||||
| Lymphocytes | Q1 | −3.37 (1.01) | −0.05 (0.14) | −0.61 (0.61) | 0.06 (0.07) | ||||
| Q2 | −3.75 (1.13) | 0.22 | −0.05 (0.15) | 0.68 | −0.93 (0.50) | 0.11 | −0.03 (0.06) | 0.80 | |
| Q3 | −1.38 (1.21) | −0.02 (0.17) | −0.42 (0.46) | 0.03 (0.05) | |||||
| Monocytes | T1 | 0.92 (0.87) | 0.22 | −0.07 (0.11) | 0.41 | −0.34 (0.47) | 0.38 | −0.05 (0.06) | 0.47 |
| T2 | −0.52 (0.88) | 0.12 (0.12) | 0.55 (0.46) | −0.12 (0.05) | |||||
| PP | |||||||||
| Neutrophils | Q1 | 4.72 (1.19) | −0.40 (0.17) | 1.17 (0.73) | −0.002 (0.10) | ||||
| Q2 | 2.05 (1.13) | <.0001 | −0.34 (0.17) | 0.01 | 0.55 (0.74) | 0.02 | 0.03 (0.10) | 0.94 | |
| Q3 | 1.90 (0.87) | 0.02 (0.13) | 0.07 (0.75) | 0.01 (0.11) | |||||
| Lymphocytes | Q1 | −3.66 (1.05) | 0.31 (0.16) | −1.65 (0.64) | 0.05 (0.09) | ||||
| Q2 | −4.01 (1.18) | 0.0003 | 0.30 (0.18) | 0.06 | −1.19 (0.53) | 0.01 | 0.06 (0.08) | 0.43 | |
| Q3 | −1.66 (1.25) | 0.19 (0.19) | −1.11 (0.48) | 0.02 (0.07) | |||||
| Monocytes | T1 | −0.65 (0.90) | 0.45 | 0.05 (0.13) | 0.74 | −0.32 (0.50) | 0.43 | −0.01 (0.07) | 0.88 |
| T2 | −0.06 (0.92) | 0.07 (0.14) | 0.53 (0.49) | −0.01 (0.07) | |||||
*
in a linear mixed model, adjusted for age, sex, center, diabetes, BMI, total cholesterol, smoking, drinking, physical activity, and dietary sodium intake.
Q1=highest quartile, Q4=lowest; T1=highest tertile, T3=lowest. The reference category was Q4 (lowest quartile) or T3 (lowest tertile).
Abbreviations: BP, blood pressure; SBP, systolic blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure; SE, standard error.