TABLE 3.
Multivariable-adjusted Backwards Elimination Linear Regression Models for Relations Between Inflammatory Markers & Fata.
| Model: | 1 | 2 | 3 | 4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Clinical Covariates Onlyb | Clinical Covariatesb + Markers | P | + BMI & WC | P | + BMI & WC + Abdominal Visceral Fat | P | + BMI & WC + Additional Covariatesc | P | |
|
Pericardial Fat | |||||||||
| CRP | --- | 18.0 (13.7-22.2) | <0.0001 | 6.8 (2.6-10.9) | <0.01 | --- | --- | 6.1 (1.9-10.3) | <0.01 |
| Interleukin-6 | --- | 4.3 (0.8-7.7) | 0.02 | --- | --- | --- | --- | --- | --- |
| MCP-1 | --- | 4.4 (1.1-7.6) | <0.01 | 3.4 (0.3-6.4) | 0.03 | --- | --- | 3.1 (0.02-6.1) | <0.05 |
| Model R2 | 0.046 | 0.244 | 0.338 | 0.496 | 0.351 | ||||
|
Intrathoracic Fat | |||||||||
| CRP | --- | 25.1 (20.5-29.6) | <0.0001 | 12.3 (7.9-16.6) | <0.0001 | 6.8 (3.3-10.3) | 0.0001 | 11.9 (7.4-16.3) | <0.0001 |
| Interleukin-6 | --- | 4.0 (0.3-7.6) | 0.03 | --- | --- | --- | --- | --- | --- |
| MCP-1 | --- | 5.0 (1.6-8.5) | <0.01 | 3.9 (0.7-7.1) | 0.02 | --- | --- | 3.8 (0.6-7.0) | 0.02 |
| Model R2 | 0.034 | 0.425 | 0.503 | 0.692 | 0.509 | ||||
a
Expressed as change in fat volume (cm3 (95% CI)) per inter-quartile increase in log inflammatory marker concentration.
b
Adjusted for age, sex, current smoking, heavy alcohol use, aspirin use, menopausal status and hormone replacement therapy.
c
Adjusted for blood pressure, lipid treatment, total cholesterol/HDL, triglycerides, diabetes mellitus, and cardiovascular disease.