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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: JALA Charlottesv Va. 2010 Dec 1;15(6):455–463. doi: 10.1016/j.jala.2010.08.003

Figure 1.

Figure 1

Cross sectional view through a monolithic membrane valve. The microvalves are composed of a featureless PDMS membrane sandwiched between a discontinuous fluidic channel and a pneumatic displacement chamber. (A) The valves are normally closed with the PDMS membrane resting on the valve seat. Application of a vacuum to the displacement chamber through a control channel pulls the PDMS membrane away from the discontinuity, allowing fluid to fill the chamber and/or flow across the discontinuity in the fluid channel. (B) Three independently actuated microvalves in series form an integrated micropump for transport of samples and reagents.