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Postnatal lethality and growth retardation in ShhΔSBE1/– pups. (A) The percentage of ShhΔSBE1/– mouse pups (Δ/–; square points) surviving the first postnatal week is significantly reduced compared with wild-type (WT; round points) and ShhΔSBE1/ΔSBE1 mutants (Δ/Δ; triangle points). (B) Body weight is significantly reduced in ShhΔSBE1/– pups in the first postnatal week compared with wild-type and ShhΔSBE1/ΔSBE1 mutants. Data are expressed as mean ± s.e.m.
