Figure 3.
AMPAR surface expression in the DS, detected with GluR2/3 antibody, is decreased after 15 days of withdrawal from repeated cocaine injections. Data are expressed as average percent change from saline controls for GluR1 (a; Sal N=8, Coc N=11), GluR2 (b; Sal N=10, Coc N=12), and GluR2/3 (c; Sal N=9, Coc N=12). In contrast to the NAc (Figure 2), GluR1, and GluR2 distribution in the DS were not significantly altered, whereas GluR2/3 surface and total levels were significantly decreased (*p<0.05). Representative bands are shown at the bottom of each panel.