Table 2.

—Magnitude of the Changes in Exhaled Breath Condensate Composition Mediated by Deep Inspiration/Forced Exhalation, Increased V.e, and Acute Bronchoconstriction

		Difference Introduced by Physiologic Factors
Physiologic Factors	Characteristics	Deep Inspiration/ Forceful Exhalation	Increased $\dot{\text{V}}$e (Exercise)	Increase in Raw (Methacholine)
EBC volume, mL	No.	17	16	13
	Baseline, mean ± SD	1.63 ± 0.40	1.38 ± 0.33	1.51 ± 0.40
	Mean change ± SD	−0.10 ± 0.34	0.65 ± 0.43	0.03 ± 0.36
	Mean change relative to baseline, %	−6.3	47.3	1.7
	95% CI for mean change relative to baseline, %	(−16, 4)	(32, 63)	(−11, 15)
CysLT levels, pg/mL	No.	18	16	14
	Baseline, mean ± SD	4.18 ± 3.48	4.23 ± 4.15	3.89 ± 4.12
	Mean change ± SD	−0.58 ± 1.30	−0.19 ± 1.41	−0.21 ± 1.84
	Mean change relative to baseline, %	−13.9	−4.5	−5.4
	95% CI for mean change relative to baseline, %	(−28, 0)	(−21, 12)	(−30, 19)
ASL dilution	No.	18	16	15
	Baseline, mean ± SD	5,353 ± 2,353	5,034 ± 2,327	5,434 ± 1,944
	Mean change ± SD	−16 ± 2,383	462 ± 2,557	208 ± 2,109
	Mean change relative to baseline, %	−0.3	9.2	3.8
	95% CI for mean change relative to baseline, %	(−21, 20)	(−16, 34)	(−16, 23)
ASL CysLT levels, ng/mL	No.	18	16	15
	Baseline, mean ± SD	20.30 ± 21.19	22.55 ± 30.07	20.99 ± 24.44
	Mean change ± SD	2.17 ± 19.60	0.99 ± 11.92	−0.46 ± 19.25
	Mean change relative to baseline, %	9.7	4.4	−2.2
	95% CI for mean change relative to baseline, %	(−31, 50)	(−26, 30)	(−46, 50)

ASL = airway surface liquid; CysLT = cysteinyl leukotriene; EBC = exhaled breath condensate inspiration. See Table 1 for expansion of other abbreviations.