Table 2.
Estimated changes in ECG variables over time with t base as reference point. Estimates are based on a statistical model fit to each variable.
| Time | ||||
|---|---|---|---|---|
| t 15 | t hypo | t post | ||
| Method | Variable | β (SE) 95% CI | β (SE) 95% CI | β (SE) 95% CI |
| MA | RR (ms) | −55 (16)† [−92;-18] | −87(14)‡ [−121;−53] | −64(15)‡ [−99;−29] |
| QTcF (ms) | 5 (2) [−1;10] | 1(2) [−4;5] | 1(2) [−4;6] | |
| QTcB (ms) | QTcB (ms) | 9 (3)† [3;15] | 7(2)† [2;13] | 6(2)† [1;12] |
| T/R Ratio (−) | −0.07 (0.01)‡ [−0.1;−0.05] | −0.1(0.01)‡ [−0.12;−0.08] | −0.06 (0.01)‡ [−0.08;−0.04] | |
|
| ||||
| SI | RR (ms) | −60 (16)‡ [−97; −23] | −98(14)‡ [−132;−64] | −69(15)‡ [−105; −34] |
| QTcF (ms) | 30 (6)‡ [15;44] | 35(6)‡ [22;48] | 8(6) [−5;22] | |
| QTcB (ms) | 34 (7)‡ [19;50] | 42(6)‡ [28;56] | 13(6) [−1;28] | |
| T/R Ratio (−) | −0.08 (0.01)‡ [−0.1; −0.06] | −0.1(0.01)‡ [−0.12; −0.08] | −0.06 (0.01)‡ [−0.08; −0.04] | |
Significances (compared with t baseline): † P < .05, ‡ P < .001.