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Schematic representation of hypothesized interactions between E-cadherin, β- οr γ-catenin, and PS1. β-Catenin or γ-catenin binds E-cadherin at amino acids 677–706. PS1 C-terminal fragment binds E-cadherin close to the membrane at amino acids 604–615 (required for PS1/E-cadherin complex formation). For more details see text.
